For example, some topical steroids will be classified one or two strengths higher when moving from cream to ointment. The ointment base was prepared and formulation of ointment was done by incorporating the active ingredients in most effective ratio in the base by trituration. And some are greasy, others give protection to the skin and others have their own healing qualitiy. As a rule of thumb, an ointment base is more occlusive and will drive the medication into the skin more rapidly than a solution or cream base. 1st Jan 1970 Education Reference this Disclaimer: This work has been submitted by a university student. You can mix several thickeners in … You can view samples of our professional work here. Contain accurate dose . Some are stronger, others weaker. Formulation of ointment and cream. pH of these solutions was measured using the Mettler Toledo InLab®Micro pH probe (Electrolyte 3 mol/L KCl). Begin by taking some ointment and fill the bottom of the ointment jar, and use the spatula to put some ointment into the crevices. Provide drug in a form for absorption or other delivery to the target . This is not an example of the work produced by our Essay Writing Service. PHM4153 Dosage Design 2 2011/12. An ointment-like base comprises a blend of at least one topically acceptable alkyl ester of an aromatic carboxylic acid and at least one topically acceptable dialkyl ester of a hydroxyalkanedicarboxylic acid, the ratio of the two esters being from about 1:3 to 4:1. Continue adding ointment to the jar again using the spatula to put the ointment along the sides of the jar. 4708 words (19 pages) Essay. Thickeners are all substances that make a cream or ointment out of the liquid oil and water. Uniformity of Drug Content Predetermined amount of ointment formulation was tak-en from three different regions of an ointment jar and was dissolved in methanol. an ointment base is selected that will produce a product that may be readily applied to the required site. Retain quality throughout shelf life & usage period Convenient to take or administer . Choice of base formulation. After preparing the ointment, one must select an ointment jar that will just hold all of the formulation. to get final ointment concentrations of 1% w/v,5%w/v, and 10% w/v. The different thickeners work in different ways. Formulation requirement: efficacy, safety, and quality. A medication's potency often is changed with its base. In light of the high drug content, this point is particularly important in the formulation of pastes. Their own healing qualitiy the Mettler Toledo InLab®Micro ph probe ( Electrolyte 3 mol/L KCl ) produce a that. 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