A person may want to come off statins for various reasons. Some patients decide to stop taking statins, a cholesterol-lowering drug, if they experience side effects. N-of-1 Trial of a Statin, Placebo, or No Treatment Patients who had discontinued statins because of side effects received four bottles of a statin, four … ... 20% of people can’t tolerate the side effects of statins, ... be subject to change without notice. Staph skin and soft tissue infections are a potentially new statin side effect. Data from the 2008 JUPITER trial show that 54 per cent of those at risk of heart disease used statins as a preventive drug to reduce their risk of heart attack and 48 per cent to reduce their risk of stroke. No one should stop taking a statin (or any drug for that matter) without first checking with the prescribing physician. But unlike statins, researchers say, it works in the liver only and cannot reach the muscles. There will need to be additional research to determine whether this is a real complication of statins. And more people stopped taking the new drug because of side-effects than people in the dummy pill group. Some common examples include: Side effects. Any attention to statin side effects needs to be retaliated by the fact that statins reduce the risk of people dying of heart attacks, heart disease or stroke. A new study tracked how they did. For people who can’t tolerate the side effects from statins, there may be a new option.