The statins are generally taken once daily and are available in generic forms. There is evidence favoring primary prevention with statins for high-risk patients. Background: Although most patients with hypercholesterolemia require life-long therapy with statins, these drugs are underused due to high costs. Don't Panic, Everything Goes to Pot: Myths Are Driving FDA, CDC Vaping Policy, What the Hulk? They have also been associated with increases in blood sugar, which in some cases leads to a diagnosis of diabetes. We raise our funds each year primarily from individuals and foundations. Helping Smokers Quit: The Science Behind Tobacco Harm Reduction, Foods Are Not Cigarettes: Why Tobacco Lawsuits Are Not a Model for Obesity Lawsuits, The Prevention and Treatment of Osteoporosis: A Review. A sample size of 400 patients between the age of 40–70 years, taking simvastatin 40 mg for at least 6 months or more were selected. Statins can cause muscle pain, and in a small number of individuals, more significant muscle injury and rarely liver problems. Statins may have the same cholesterol lowering effects when given every other day, supported by the fact that it takes several weeks for cholesterol levels to return to baseline after treatment with statins is stopped. Alternate-Day Statin Dosing May be as Effective, and Cheaper, The Next Plague and How Science Will Stop It. Abstract. Alternate day therapy, with or without vitamin D supplementation, may be used by the physicians for troublesome muscular complains. The overall prevalence of myalgia was 7% (28/400). New cholesterol guidelines suggest a statin may be in your future, Dispatch: For Those With High Cholesterol: Nuts to You, Perceptions of statin side-effects greatly outnumber actual threat, Concussion Prevention: Sorting Through the Science to See What's Sound, No Evidence that Blue-Light Blocking Glasses Help with Sleep, Dutch Newspaper 'De Telegraaf' Accuses Scientists of Being Corporate Publicists. Frequency of myalgia in patients taking simvastatin everyday (n = 20, 10%) was significantly higher compared to those taking it every alternate day (n = 8, 4%) (p = 0.02). Alternate day treatment will be less expensive, and non-daily dose of certain statins may reduce the already-low but concerning incidence of musculoskeletal pain and weakness that can be a side effect of statin use. © 2017 Published by Elsevier B.V. on behalf of Cardiological Society of India. Most of studies reviewed demonstrated that when compared with baseline, every-other-day dosing of statins significantly lowered low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels. This effect will certainly not go away in the day during which a pill is skipped. ACSH does not have an endowment. How Toxic Terrorists Scare You With Science Terms, Adult Immunization: The Need for Enhanced Utilization, IARC Diesel Exhaust & Lung Cancer: An Analysis. In our cross sectional study, we took 400 patients taking simvastatin for at least past 6 months, and those who were complaining of Myalgia were further investigated for vitamin D levels. Objectives: The authors sought to evaluate the safety and efficacy of atorvastatin administered every other day in patients with hypercholesterolemia. 95% of Baby Food Tainted with Toxic Metals? The most common cited triggering factor for pain was physical exercise. Advertising Policy. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. Statins may have the same cholesterol lowering effects when given every other day, supported by the fact that it takes several weeks for cholesterol levels to return to baseline after treatment with statins is stopped. Coronavirus: Fear of a Pandemic, or a Pandemic of Fear? Traditional Holiday Dinner Replete with Natural Carcinogens - Even Organic Thanksgiving Dinners, A Primer On Dental Care: Quality and Quackery, Nuclear Energy and Health And the Benefits of Low-Dose Radiation Hormesis, Priorities in Caring for Your Children: A Primer for Parents, Endocrine Disrupters: A Scientific Perspective, Good Stories, Bad Science: A Guide for Journalists to the Health Claims of "Consumer Activist" Groups, A Comparison of the Health Effects of Alcohol Consumption and Tobacco Use in America. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Statins everyday versus alternate days: Is there a difference in myalgia rates? Further supporting this concept is the fact that total cholesterol … Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The American Council on Science and Health is a research and education organization operating under Section 501(c)(3) of the Internal Revenue Code. Every-other-day therapy could be one strategy to resolve this problem. This cross sectional study was conducted in a tertiary care hospital of Pakistan. Subjects were evaluated for myalgia via a self-administered questionnaire, and those complaining of myalgia were then evaluated for serum vitamin D levels. Contributions are fully tax-deductible. The following are 10 points to remember about alternate-day dosing with statins: 1. In another study involving the randomizing of participants into three groups, one taking 10 mg of atorvastatin (Lipitor) every other day, one taking 10 mg every day and the last taking 20 mg every other day over a period of six weeks, it was found that the reduction of LDL-C was lowest in patients taking 20 mg every other day, but this was complicated by the fact that those patients receiving 10 mg every other day had higher levels of LDL-C at the start. 9/11 Truther Mark Ruffalo Testifies to Congress on Science, Nothing Grimes Said About Eyeballs or Depression Makes Any Sense, Jeff Bezos' Plan to Colonize Space is Based on Sheer Nonsense, Robert F. Kennedy, Jr. is Helping Spread Flu and Cervical Cancer, Anti-Monsanto Lawyer and USRTK, Carey Gillam Collaborator Possibly Headed to Prison for Extortion, Journalist Peter Fairley Cites Anti-Vaxx Website, Spreads Misinformation on Flu, COVID-19, DeSmogBlog: Climate Website Is Headed by Anti-Vaxxer Brendan DeMelle, DeSmogBlog: Climate Activist Site Smears Freeman Dyson and Other Scientists. By continuing you agree to the use of cookies. The size of the decrease has been shown to be similar to that seen in patients receiving daily statin therapy. Patients with prior musculoskeletal or neuromuscular complains, and family history of muscular disorders were excluded. Here is some good news for those of you among the millions taking statins you may not need to take them daily. COVID Infection Fatality Rates by Sex and Age, Comparing COVID Vaccines: Pfizer vs. Moderna vs. AstraZeneca/Oxford, COVID: Asymptomatic Cancer Patient Was a One-Woman Super-Spreader, COVID-19, Viral Load and Shedding: An Update, Why Pfizer's Vaccine Must Be Stored in the Deep, Deep Freeze, Thank You, Trial Lawyers, For Protecting Us from the Scourge of Baby Powder. Background: Statins have efficacy in lowering cholesterol and reducing cardiovascular events but their cost is a major disadvantage. And Metz and Lucas, in a 2001 study, cautioned that it is difficult to predict which patients will benefit most from alternate-day therapy. Based on our findings, we conclude that ADD was better tolerated by patients than EDD. Objective: To compare the efficacy and safety of rosuvastatin 10 mg administered every other day versus once daily. There was no significant difference between the time of onset, nature, severity, type, or location of myalgia between the 2 groups. [7,8] Thus, it is conceivable that alternate-day treatment might be effective in maintaining the lipid-lowering efficacy of atorvastatin. No treatment is without some risk. Therefore, atorvastatin given on alternate days may be … Patients with coronary disease should be treated with statins to achieve an low-density lipoprotein cholesterol (LDL-C) <100 mg/dl and <70 mg/dl for very high-risk patients. The parallel is seen most consistently in patients in the alternate-day … Data was analyzed through SPSS 16.0 and compared using chi square test. In a 1999 study of 69 patients randomized to two groups, one given 10 mg of simvastatin every day and the other group given the same dose every other day, no difference was found in the LDL-C value between the two groups at the 6 month follow-up.